WISHART, NEIL,ARGIRIADI, MARIA A.,CALDERWOOD, DAVID J.,ERICSSON, ANNA M.,FIAMENGO, BRYAN A.,FRANK, KRISTINE E.,FRIEDMAN, MICHAEL,GEORGE, DAWN M.,GOEDKEN, ERIC R.,JOSEPHSOHN, NATHAN S.,LI, BIQIN C.,MOR
申请号：
PE0007452012
公开号：
PE13362012A1
申请日:
2010.12.01
申请国别(地区):
PE
年份:
2012
代理人:
摘要：
Referring to a tricyclic Compound of formula (i), where t is n, CR6, or NR6, S u is n or X is Cr3 and CR4 NR1 and is n or C R1, R2 and R5 are h, halogen, deuterium, NO2, among others R3 is H, cycloalkyl C1 - C5 - C8 C12 alkyl R4 and R6 are h, halogen, deuterium, CF3, CHF2, CH2f, among others. You.Preferred compounds are: N - (1 - (5h pyrrolo [2,3-e] [1,2,4] triazolo [4,3] pirazin alpha - 1 - yl) methyl) cyclobutyl 2-cyanoacetamide) -, (S) - 1 - ((1 - (cyclopropylsulfonyl) pyrrolidin-3-yl) methyl) - 5h pyrrolo [2,3-e] [1,2,4] triazolo [Alpha] pyrazine 4.3, (S) - 5 - (3 - (5h pyrrolo [2,3-e] [1,2,4] triazolo [4,3] pirazin alpha - 1 - il) i Til) pyrrolidin-1-yl) pirazin - 2 - carbonitrilo, among others.It also relates to a Pharmaceutical composition. These compounds are useful in the treatment of cardiovascular diseases, autoimmune diseases, cancer, among othersREFERIDA A UN COMPUESTO TRICICLICO DE FORMULA (I), DONDE T ES N, CR6, O, NR6, S U ES N O CR4 X ES CR3 O NR3 Y ES N O C R1, R2 Y R5 SON H, DEUTERIO, HALOGENO, NO2, ENTRE OTROS R3 ES H, CICLOALQUILO C5-C12, ALQUILO C1-C8, ENTRE OTROS R4 Y R6 SON H, HALOGENO, DEUTERIO, CF3, CHF2, CH2F, ENTRE OTROS. SON COMPUESTOS PREFERIDOS: N-(1-((6H-PIRROLO[2,3-e][1,2,4]TRIAZOLO[4,3-ALFA]PIRAZIN-1-IL)METIL)CICLOBUTIL)-2-CIANOACETAMIDA, (S)-1-((1-(CICLOPROPILSULFONIL)PIRROLIDIN-3-IL)METIL)-6H-PIRROLO[2,3-e][1,2,4]TRIAZOLO[4,3-ALFA]PIRAZINA, (S)-5-(3-((6H-PIRROLO[2,3-e][1,2,4]TRIAZOLO[4,3-ALFA]PIRAZIN-1-IL)METIL)PIRROLIDIN-1-IL)PIRAZIN-2-CARBONITRILO, ENTRE OTROS. TAMBIEN ESTA REFERIDA A UNA COMPOSICION FARMACEUTICA. DICHOS COMPUESTOS SON UTILES EN EL TRATAMIENTO DE ENFERMEDADES CARDIOVASCULARES, ENFERMEDADES AUTOINMUNES, CANCER, ENTRE OTROS
