Disclosed herein are recombinant proteins including an IGFBP3 or a biologically active fragment thereof and an IgG Fc portion linked to the C-terminus of the IGFBP3 variant. The recombinant proteins including at least one additional domain of other growth factors are also disclosed. Methods for treating tumors, in particular, tumors resistant to the targeted therapy, using the above-mentioned recombinant proteins are also provided.本揭示內容是關於一種重組蛋白,其包含一IGFBP3或其生物活性片段,以及連結至IGFBP3變異體之C端的IgG Fc部。本發明重組蛋白包含其他生長因子的至少一額外域。本揭示內容亦提供一種利用前述重組蛋白治療腫瘤(特別是對標靶治療具有抗藥性的腫瘤)的方法。
