THE BOARD OF TRUSTEES OF THE UNIVERSITY OF ILLINOIS
发明人:
METCALF, WILLIAM W.,JU, KOU-SAN,GAO, JIANGTAO,DOROGHAZI, JAMES R.,LABEDA, DAVID P.,VAN DER DONK, WILFRED A.
申请号：
CA2954667
公开号：
CA2954667A1
申请日:
2015.07.21
申请国别(地区):
CA
年份:
2016
代理人:
摘要：
The present invention relates to pharmaceutical compositions comprising a phosphonic acid compound, such as a natural product. Such compounds can include, such as an antibiotic or compound with other activity, derived from an Actinobacteria strain having a gene encoding pepM (phosphoenolpyruvate phosphomutase) or a pepM-dependent biosynthetic pathway. The present invention also relates to methods for treating or preventing or reducing the risk of a bacterial infection by administering a therapeutically effective or prophylactically effective amount of a phosphonic acid antibiotic, or a pharmaceutical composition containing such an antibiotic, to a patient or subject in need thereof. The present invention further relates to methods for isolating, purifying, and identifying such phosphonic acid compounds from Actinobacteria strains.
