The present invention relates to a controlled-release pharmaceuticalformulation comprising at least one active in-gredientdispersed in a matrix comprising at least one slow-release excipientcomprising an association of at least one glycogen andat least one alginate with alkaline-earth metal salts, and a process for itspreparation. The invention also relates to a slow-releaseexcipient comprising an association of at least one glycogen and at least onealginate with alkaline-earth metal salts, and the processfor its preparation, and its use for the preparation of slow-releasepharmaceutical formulations.