pharmaceutical composition, and methods for reducing plaque burden in an animal's retinal ganglion cell layer, for reducing the amount of plaque in an animal's retinal ganglion cell layer, for decreasing the total amount of soluble beta-amyloid retinal ganglion cell layer of an animal to prevent, treat and / or alleviate the effects of eye disease associated with pathological abnormalities / changes in visual system tissue, to monitor minimal residual eye disease associated with pathological abnormalities / changes in visual system tissues, to predict a patient's responsiveness, and to retain
Andrea Pfeifer,Andreas Muhs,Maria Pihlgren,Ryan Watts
申请号：
BRPI0818623
公开号：
BRPI0818623A2
申请日:
2008.10.03
申请国别(地区):
BR
年份:
2017
代理人:
摘要：
The present invention provides novel methods and compositions comprising highly specific and highly effective antibodies that specifically recognize and bind to specific epitopes from a range of ²-amyloid proteins. The antibodies of the present invention are particularly useful for the treatment of ocular diseases associated with pathological abnormalities/changes in the tissues of the visual system, particularly associated with amyloid-beta-related pathological abnormalities/changes in the tissues of the visual system.
