The present invention discloses formula (I) compound and/or its salt, wherein R is-OH or-OP (O) (OH) 2. Invention further discloses use above compound as the method for the selective agonist of g protein coupled receptor S1P1, and the pharmaceutical composition comprising above compound. These compounds with what treatment, prevention disease or illness (such as autoimmune disease and vascular diseases) or can slow down its progress in a variety of therapy fields.本發明披露了式(I)化合物和／或其鹽其中R爲-OH或-OP(O)(OH)2。本發明還披露了使用上述化合物作爲G蛋白偶聯受體S1P1的選擇性激動劑的方法，以及包含上述化合物的藥物組合物。這些化合物可在多種治療領域中用於治療、預防疾病或病症（例如自身免疫性疾病和血管疾病）或减慢其進展。
