Parag Aggarwal;Timothy Charles Meredith;Ronald Wesley Woodard
发明人:
Ronald Wesley Woodard,Timothy Charles Meredith,Parag Aggarwal
申请号：
US11655413
公开号：
US08303964B2
申请日:
2007.01.19
申请国别(地区):
US
年份:
2012
代理人:
摘要：
The present invention provides non-toxic Gram-negative bacteria. In particular, the present invention provides viable Gram-negative bacteria (e.g., E. coli) substantially lacking lipopolysaccharide (LPS, endotoxin) within the outer membrane. The present invention further provides methods of generating viable non-toxic Gram-negative bacteria and uses thereof. The present invention also provides compositions and methods for inducing immune responses and for researching and developing therapeutic agents.
