Phillip C. Liu,Alla Volgina,Richard Wynn,Nina Zolotarjova,Liangxing Wu,Kaijiong Xiao,Song Mei,Liang Lu,Wenyu Zhu,Yingda Ye,Haisheng Wang,Ding-Quan Qian,Wenqing Yao
申请号：
US15851497
公开号：
US20180177870A1
申请日:
2017.12.21
申请国别(地区):
US
年份:
2018
代理人:
摘要：
Compositions and methods for inducing PD-L1 internalization are disclosed. The methods include reducing the amount of cell surface PD-L1 by contacting a cell expressing PD-L1 with a compound that binds to cell surface PD-L1 and induces PD-L1 internalization. Compounds that induce PD-L1 internalization can be used to enhance, stimulate and/or increase an immune response and treat a PD-1-related disease or condition.
