OBSHCHESTVO S OGRANICHENNOJ OTVETSTVENNOSTJU "NIZHEGORODSKIJ LAZERNYJ TSENTR"
发明人:
GOLUBJATNIKOV GERMAN JUREVICH,Голубятников Герман Юрьевич,KAMENSKIJ VLADISLAV ANTONIEVICH,Каменский Владислав Антониевич,MASLENNIKOVA ANNA VLADIMIROVNA,Масленникова Анна Владимировна,ORLOVA ANNA GENNA
申请号：
RU2012147608/14
公开号：
RU0002498767C1
申请日:
2012.11.08
申请国别(地区):
RU
年份:
2013
代理人:
摘要：
FIELD: medicine.SUBSTANCE: invention refers to medicine, namely to radiation therapy, and may be used for the non-invasive detection of tissue oxygen status of the tumour and surrounding healthy tissues. For this purpose, the above tissues are exposed to a radiomodifying agent. An optical diffusion spectroscopy method is used to scan the analysed tissues before and also several times after the exposure to the radiomodifying agent. That is followed by calculating the concentrations of oxidised, reduced and total hemoglobin and the oxygen status of the analysed tissues. Then the flow charts for the oxidised, reduced and total haemoglobin concentrations, the oxygen status of the analysed tissues. A time interval with maximum oxygen status variation and surrounding normal tissues is calculated by the flow chart for the oxygen status of the tumour tissue and the surrounding normal tissues, in case of an increase of the oxygen status of the tumour tissue. The given interval is to be considered as an optimum for the highest damaging action of ionising radiation on the tumour tissues, and the safe one for the surrounding normal tissues. The flow charts for the oxidised, reduced and total haemoglobin concentrations are used to determine the mechanism of action of the radiomodifying agent on the analysed tissues.EFFECT: method enables specifying the radiomodifying parameters, such as an agent type, a dose of the radiomodifying agent that is an optimum for the highest damaging action of ionising radiation on the tumour tissues and the safe one for the surrounding normal tissues.4 cl, 3 dwgИзобретение относится к медицине, а именно к лучевой терапии, и может быть использовано для неинвазивного определения кислородного статуса тканей опухоли и окружающих нормальных тканей. Для этого указанные ткани подвергают воздействию радиомодифицирующего агента. Затем методом оптической диффузионной спектроскопии осуществляют сканирование исследуемых тканей до, а также несколько раз после во
