A process of preparing a quinolone carboxylic acid or its derivatives having Formula I, Ia, or IV, as shown herein, comprises using a starting quinolone that already has one or more desired substituents at one or more particular positions on the quinolone ring and preserving the orientation of such substituents throughout the synthesis. The present process comprises fewer steps than prior-art processes. The present process also can include a simple separation of a desired enantiomer of the quinolone carboxylic acid or its derivatives from the enantiomeric mixture. Pharmaceutical compositions comprising fluoroquinolones prepared by the present process can be used effectively against a variety of microbial pathogens.本發明揭示一種製備具有如本文中所示之式I、Ia或IV的喹啉酮羧酸或其衍生物之方法,其包含使用已在喹啉酮環上之一或多個特定位置處具有一或多個所需取代基的起始喹啉酮,且在整個合成期間維持該等取代基之定位。本發明之方法比先前技術之方法包含較少步驟。本發明之方法亦可包括將喹啉酮羧酸或其衍生物之所需對映異構物自對映異構混合物中簡單分離。包含由本發明方法製備之氟喹啉酮之醫藥組合物可用於有效對抗多種微生物病原體。
