A Salacia composition described herein significantly reduces appetite, activates Hormone Sensitive Lipase, and manages a healthy lipid profile through inhibition of HMG-CoA Reductase enzyme. Salacia compositions described herein include of at least 12% of polyphenols, 2% of mangiferin and 1% of 25, 26-oxidofriedelane-1, 3-dione by weight of the composition in the form of extract. The composition is obtained by continuous solvent extraction, employing non-aqueous food grade solvents. Salacia compositions herein reduce appetite by about 18% of routine diet, when effective amounts are administered to a subject in need thereof. Effective management of a healthy lipid profile is thus possible with synergistic combination of reduction in energy intake, activation of Hormone Sensitive Lipase, and inhibition of HMG-CoA Reductase enzyme responsible for cholesterol metabolism.一種於本文中所描述的五層龍屬組成物,其明顯減低食慾、活化激素敏感脂酶及透過抑制HMG-CoA還原酶酵素管理健康脂質廓形。於本文中所描述的五層龍屬組成物係呈萃取物形式,其包括至少12%多酚類、2%芒果苷及1%的25,26-氧化木栓烷-1,3-二酮,以該組成物的重量計。該組成物係使用非水性食品級溶劑,藉由連續溶劑萃取獲得。於本文中的五層龍屬組成物當以有效量投藥至需要其的患者時,其減低食慾約例行飲食的18%。因此,伴隨著減少能量攝取、活化激素敏感脂酶及抑制是膽固醇代謝原由的HMG-CoA還原酶酵素之協同組合,有效管理健康脂質廓形係可能的。
