The present invention provides for the identification of an antigen surrogate to the native antigens for the autoimmune disease pemphigus vulgaris. Ligands are discovered using large random peptoid or cyclic peptoid libraries that are screened against known antibodies to autoimmune diseases. The ligands may be useful as drugs in the treatment of such diseases and can also be used in combination with the comcomitant removal of T-cells associated with autoimmune disorders.La presente invención se refiere a un método para identificar un ligando peptoide restringido sustituto de antígeno que se reconoce específicamente por autoanticuerpos que comprende: exponer un anticuerpo asociado con una enfermedad autoinmunes seleccionada de pénfigo vulgar a una biblioteca de lingando peptoide que comprende ligandos peptoides de la formula I.