A system (100) for a targeted perfusion scan includes a computed tomography (CT) scanner (120), a feeding territory map (132) and a targeted perfusion unit (140). The CT scanner (120) performs a perfusion scan of a portion of tissues of an organ. The feeding territory map (132) maps arterial locations of an arterial vessel tree to spatially located organ tissues of the organ fed by the arterial locations. The targeted perfusion unit (140) includes one or more processors (164) configured to determine targeted coverage (200) from a location of a stenosis (112, 210) and the feeding territory map, and to control the CT scanner to perform the perfusion scan according to the determined targeted coverage.
