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COMBINED THERAPY INCLUDING SGLT INHIBITORS AND DPP4 INHIBITORS
专利权人:
МИЦУБИСИ ТАНАБЕ ФАРМА КОРПОРЕЙШН (JP)
发明人:
УЕТА Киитиро (JP),АРАКАВА Кендзи (JP),МАЦУСИТА Ясуаки (JP)
申请号:
RU2010134362/15
公开号:
RU2010134362A
申请日:
2009.01.16
申请国别(地区):
RU
年份:
2012
代理人:
摘要:
1. A method of treating or preventing diabetes or a condition associated with diabetes, comprising administering to a patient in need thereof a therapeutically effective amount of an SGLT inhibitor and a DPP4 inhibitor. ! 2. The method according to claim 1, where the SGLT inhibitor and DPP4 inhibitor is administered in an amount sufficient to reduce the level of glucose in the blood of the patient. ! 3. A method of preventing or treating a disease that is associated with a plasma level of active GLP-1, comprising administering to a patient in need thereof a therapeutically effective amount of an SGLT inhibitor and a DPP4 inhibitor. ! 4. The method according to claim 3, where the SGLT inhibitor and DPP4 inhibitor are administered in an amount sufficient to increase the level of active GLP-1 in the patient's blood plasma. ! 5. A method of increasing plasma levels of active GLP-1, comprising administering to the patient a therapeutically effective amount of an SGLT inhibitor and a DPP4 inhibitor. ! 6. The method according to claim 1, where the diabetes is type 2 diabetes! 7. The method according to claim 3, where the disease, which is associated with a plasma level of active GLP-1, is selected from diabetes, a condition associated with diabetes, myocardial infarction, learning disability, memory impairment, stroke and neurodegenerative disorder. ! 8. The method according to claim 1 or 7, where the condition associated with diabetes is selected from hyperglycemia, impaired glucose tolerance, impaired fasting glucose, insulin resistance, pancreatic beta cell insufficiency, enteroendocrine cell insufficiency, glycuria, metabolic acidosis , cataracts, diabetic nephropathy, diabetic neuropathy, diabetic retinopathy, diabetic coronary artery disease, diabetic cerebral1. Способ лечения или профилактики диабета или состояния, связанного с диабетом, включающий введение нуждающемуся в этом пациенту терапевтически эффективного количества ингибитора SGLT и ингибитора DPP4. ! 2. С
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