A novel polypeptide isolated from the cornified envelope, similar polypeptides and fragments of the polypeptide, isolated nucleotide sequences encoding the polypeptides, as well as a cosmetic and/or pharmaceutical composition containing such polypeptides are described. The polypeptides have cosmetic and/or therapeutic use to reinforce the barrier function of the epidermis, prevent and/or treat the signs of skin dryness and prevent and/or treat disorders of the barrier function or the weakening of the epidermis.
