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COMPOSIÇÕES FARMACÊUTICAS COM RESISTÊNCIA A CEA SOLÚVEL
专利权人:
AMGEN RESEARCH (MUNICH) GMBH
发明人:
SUSANNE MANGOLD,RALF LUTTERBÜSE,PETRA MAYER,DORIS RAU,EVELYNE SCHALLER,PETER KUFER,MONIKA WISSINGER,TOBIAS RAUM,ALEXANDER MURR
申请号:
PT06841112
公开号:
PT1976880T
申请日:
2006.12.21
申请国别(地区):
PT
年份:
2016
代理人:
摘要:
The present invention relates to pharmaceutical compositions for the treatment of an epithelial tumor in a human, said pharmaceutical composition comprising a bispecific single chain antibody which has a first binding domain specifically binding to human CD3, and a second binding domain specifically binding to human CEA, wherein said second binding domain comprises at least a part of the CDR-H3 or the complete CDR-H3 of murine monoclonal antibody A5B7. Furthermore, processes for the production of said pharmaceutical compositions as well as medical/pharmaceutical uses for the specific bispecific single chain antibody molecules bearing specificities for the human CD3 antigen and the human CEA antigen are disclosed.
来源网站:
中国工程科技知识中心
来源网址:
http://www.ckcest.cn/home/

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