Antibody that binds to the epidermal growth factor receptor (hegfr dimeric human)； Pharmaceutical composition that comprises； and use for treating cancer.
DALY, CHRISTOPHER,THURSTON, GAVIN,PAPADOPOULOS, NICHOLAS, J.
申请号：
CL2014003465
公开号：
CL2014003465A1
申请日:
2014.12.19
申请国别(地区):
CL
年份:
2015
代理人:
摘要：
The present invention provides antibodies that bind to EGFR and methods of using same. According to certain embodiments of the invention, the antibodies are fully human antibodies that bind to human EGFR with high affinity. In certain embodiments, the antibodies of the present invention are capable of inhibiting the growth of tumor cells expressing high levels of EGFR and/or inducing antibody-dependent cell-mediated cytotoxicity (ADCC) of such cells. The antibodies of the invention are useful for the treatment of various cancers as well as other EGFR-related disorders.La solicitud describe anticuerpos que se unen al receptor del factor de crecimiento epidérmico (EGFR, Her1 ó Erb1) para el tratamiento de tumores en pacientes que lo necesiten. En esta solicitud se desarrollaron variantes de anticuerpos, los cuales presentan alta identidad de secuencia aminoacídica con respecto a anticuerpos divulgados en el estado de la técnica.
