MEENA,BUTLER, DAVID,IWAMOTO, NAOKI,SVRZIKAPA, NENAD,VERDINE, GREGORY L.,ZLATEV, IVAN
申请号：
CA2936712
公开号：
CA2936712A1
申请日:
2015.01.16
申请国别(地区):
CA
年份:
2015
代理人:
摘要：
The present invention relates to chirally controlled oligonucleotides of select designs, chirally controlled oligonucleotide compositions, and methods of making and using the same. In some embodiments, a provided chirally controlled oligonucleotide composition provides different cleavage patterns of a nucleic acid polymer than a reference oligonucleotide composition. In some embodiments, a provided chirally controlled oligonucleotide composition provides single site cleavage within a complementary sequence of a nucleic acid polymer.
