CHARLTON MICHAEL HUGH,MOFFAT DAVID FESTUS CHARLES,DAVIES STEVEN JOHN,DRUMMOND ALAN HASTINGS
申请号：
IN4802/DELNP/2013
公开号：
IN2013DN04802A
申请日:
2013.05.30
申请国别(地区):
IN
年份:
2014
代理人:
摘要：
An imaging agent for cells which produces an intracellular imaging signal proportional to the amount of hCE 1 in the cells independently of the amount of hCE 2 and/or hCE 3 in the cells said imaging agent being a covalent conjugate of (a) an imaging agent and (b) an alpha mono or di substituted amino acid ester wherein (a) is directly linked to (b) or (a) is indirectly linked to (b) by a linker radical and wherein said direct or indirect linkage is via the amino group of (b) and wherein the amino group is not directly linked to a carbonyl group and wherein the said alpha mono or di substituted amino acid ester part is selectively hydrolysable to the corresponding carboxylic acid part by the intracellular carboxylesterase enzyme hCE 1 relative to the intracellular enzymes hCE 2 or hCE 3.
