The disclosure pertains to a perfusion system (10) that is easy to set-up, use and monitor during a bypass procedure. In some embodiments, the disclosure pertains to a perfusion system (10) in which at least some of the disposable components (14) used with the perfusion system are configured to be able to communicate set-up and/or operational parameters to the perfusion system in order to unlock further functionality (29) within the perfusion system.