ROBERT BRUCE L,SHANKARA SRINIVAS,BRONDYK WILLIAM HAROLD,SIDERS WILLIAM M
申请号：
ZA201108077
公开号：
ZA201108077B
申请日:
2011.11.03
申请国别(地区):
ZA
年份:
2013
代理人:
摘要：
The present invention relates to humanized immunoglobulins, mouse monoclonal antibodies and chimeric antibodies that have binding specificity for human CD52. The present invention further relates to a humanized immunoglobulin light chain and a humanized immunoglobulin heavy chain. The invention also relates to isolated nucleic acids, recombinant vectors and host cells that comprise a sequence which encodes a humanized immunoglobulin or immunoglobulin light chain or heavy chain, and to a method of preparing a humanized immunoglobulin. The humanized immunoglobulins can be used in therapeutic applications to treat, for example, autoimmune disease, cancer, non-Hodgkin's lymphoma, multiple sclerosis and chronic lymphocytic leukemia.
