SUNNY ABRAHAM,MARK W. HOLLADAY,SHRIPAD S. BHAGWAT,BRIAN T. CAMPBELL,QI CHAO,RAFFAELLA FARAONI,ANDILIY G. LAI,MARTIN W. ROWBOTTOM,EDUARDO SETTI,KELLY G. SPRANKLE
申请号：
PT09722418
公开号：
PT2268623E
申请日:
2009.03.17
申请国别(地区):
PT
年份:
2015
代理人:
摘要：
Compounds, compositions and methods are provided for modulating the activity of RAF kinases, including BRAF kinase and for the treatment, prevention, or amelioration of one or more symptoms of disease or disorder mediated by RAF kinases. The compound is 1-(3-(6,7-dimethoxyquinazolin-4-yloxy)phenyl)-3-(5-(1,1,1-trifluoro-2-methylpropan-2-yl)isoxazol-3-yl)urea, having the structure or a pharmaceutically acceptable salt, solvate, clathrate or hydrate thereof.
