A bone screw structure for a minimally invasive surgery contains: a body including a holder and an axial seat, the holder having a through hole and two first peripheral walls, each having first threads the screwing nail being axially connected with the axial seat of the body and having an inner orifice. The each first peripheral wall of the holder including a second side face extending therefrom, between the each first peripheral wall and the second side face is defined a V-shaped slot, and the second side face has second threads. Thereby, the two first peripheral walls of the holder of the body include two second side faces extending therefrom, and between the two first peripheral wall and the two second side faces are defined two V-shaped slots to provide an easy operating space to the bone screw and to lower an area of an opening of a wound.