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NOVEL T-CELL RECEPTOR
专利权人:
Takeda Pharmaceutical Company Limited;National Cancer Center Japan;Kyoto University
发明人:
Tetsuya Nakatsura,Toshiaki Yoshikawa,Yasushi Uemura,Kyoko Fukuda,Shin Kaneko,Atsutaka Minagawa,Yoshiaki Kassai,Atsushi Matsuda
申请号:
US16483876
公开号:
US20200010804A1
申请日:
2018.02.05
申请国别(地区):
US
年份:
2020
代理人:
摘要:
Provided is a T cell receptor containing, as α chain complementarity determining regions, respective amino acid sequences of CDR1 to CDR3 respectively shown in SEQ ID NOs: 1 to 3, or respective amino acid sequences of CDR1 to CDR3 respectively shown in SEQ ID NOs: 4 to 6, as β chain complementarity determining regions, respective amino acid sequences of CDR1 to CDR3 respectively shown in SEQ ID NOs: 7 to 9, or respective amino acid sequences of CDR1 to CDR3 respectively shown in SEQ ID NOs: 10 to 12, and capable of binding to a peptide having the amino acid sequence shown in SEQ ID NO: 27 or a complex of the peptide and HLA-A24. A T cell receptor containing, as an α chain complementarity determining regions, respective amino acid sequences of CDR1 to CDR3 respectively shown in SEQ ID NOs: 13 to 15, as β chain complementarity determining regions, respective amino acid sequences of CDR1 to CDR3 respectively shown in SEQ ID NOs: 16 to 18, and capable of binding to a peptide having the amino acid sequence shown in SEQ ID NO: 28 or a complex of the peptide and HLA-A02.
来源网站:
中国工程科技知识中心
来源网址:
http://www.ckcest.cn/home/
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