Ashley M. Vaughan;Dorender A. Dankwa;Stefan H.I. Kappe
发明人:
Ashley M. Vaughan,Stefan H.I. Kappe,Dorender A. Dankwa
申请号：
US16480615
公开号：
US20190381159A1
申请日:
2018.01.24
申请国别(地区):
US
年份:
2019
代理人:
摘要：
The disclosure relates to doubly attenuated malaria parasites that have had the functionality of LISP 2 and PlasMei2 genes interrupted through genetic manipulation. The double attenuated malaria parasites disclosed herein are useful for methods and compositions for stimulating of vertebrate host immune systems because of the complete cessation of lifecycle progression in the late liver stage, while providing a comprehensive antigenic presentation representing wildtype liver stage parasites. The disclosure also relates to the additional blood stage and gametocyte antigens to compositions of genetically attenuated malaria parasites (GAPs) to enhance efficient immune stimulation and prevention of disease and transmission related to the presence of blood stage parasites.
