DUBENSKY, THOMAS W., JR.,BROCKSTEDT, DIRK G.,BAHJAT, KEITH,HEARST, JOHN E.,COOK, DAVID
申请号：
CA2515298
公开号：
CA2515298C
申请日:
2004.02.06
申请国别(地区):
CA
年份:
2014
代理人:
摘要：
Free-living microbes are provided in which the nucleic acid has been modifiedso that the attenuated for proliferation and/or which comprise geneticmutations that attenuate the ability of the microbe to repair its nucleicacid. Methods of using the modified microbes for the loading, activation,and/or maturation of antigen-presenting cells are also provided. Vaccinecompositions comprising the modified microbes and/or the antigen-presentingcells and methods of using the vaccines are also provided. The microbes may befurther modified to include heterologous antigens, such as tumor antigens orinfectious disease antigens, for use as a vaccine against cancer or infectionsdiseases.
