1. A composition comprising a plurality of multilayer pellets comprising: a. water-soluble core b. antagonist containing layer comprising naltrexone HCl, covering the core c. sequestering polymer layer, a coating layer comprising the antagonist d. an agonist layer comprising an opioid agonist, a sequestering polymer layer coating and e. a layer with a controlled release layer coating the agonist naltrexone HCl which comprises at least 10% w / w.. opioid agonist, and wherein the agonist is substantially sequestered naltrexone HCl and substantially sequestered upon administration subektu.2. A composition according to claim 1, wherein the naltrexone HCl containing from about 10% to about 30% wt. / wt. opioid agonista.3. A composition according to claim 1, wherein the naltrexone HCl containing from about 10% to about 25% wt. / wt. opioid agonista.4. A composition according to claim 1, wherein the naltrexone HCl containing from about 10% to about 20% wt. / wt. opioid agonista.5. A composition according to claim 1, wherein the opioid agonist is oksikodon.6. A composition comprising a plurality of multilayer pellets comprising: a. water-soluble core b. antagonist containing layer comprising naltrexone HCl, covering the core c. sequestering polymer layer, a coating layer comprising the antagonist d. an agonist layer comprising the opioid agonist, the polymer coating layer is sequestered and e. a layer with a controlled release layer coating the agonist, wherein the naltrexone HCl composition comprises at least 5% of the combined weight of the water-soluble core layer and the layer sequester the antagonist of the polymer, and where arg1. Композиция, содержащая множество многослойных драже, содержащих:a. водорастворимое ядроb. антагонист, содержащий слой, включающий налтрексон HCl, покрывающий ядроc. слой секвестрирующего полимера, покрывающий слой, содержащий антагонистd. слой агониста, включающий опиоидный агонист, покрывающий слой секвестрирующего полимера иe. слой с контр
