Kent B. THUDIUM,Alan J. KORMAN,Heidi LEBLANC,Mark YAMANAKA,Mark SELBY,Kyra D. ZENS
申请号：
HK16100937.8
公开号：
HK1212911A
申请日:
2016.01.28
申请国别(地区):
HK
年份:
2016
代理人:
摘要：
The present disclosure provides isolated human monoclonal antibodies and antigen-binding portions thereof that bind to human LAG-3, in particular antibodies and antigen-binding antibody portions that can inhibit the binding of LAG-3 to MHC Class II molecules and that can stimulate antigen-specific T cell responses. Nucleic acid molecules encoding the antibodies and antigen-binding antibody portions of the invention as well as compositions and immunoconjugates of the antibodies and antigen-binding antibody portions of the invention are also provided. This disclosure also provides for the use of the antibodies and antigen-binding antibody portions of the invention in therapy.
