The object of the present invention is a pharmaceutical tablet composition comprising an NSAID and a PPI and having improved stability and bioavailability. The present invention relates to a pharmaceutical tablet composition comprising: a) a multilayer tablet core comprising: i) a non-steroidal anti- inflammatory drug (NSAID) layer comprising an NSAID and at least one pharmaceutically acceptable excipient； ii) an optional middle layer； iii) a proton pump inhibitor (PPI) layer comprising multiple units of PPI coated with a protective coating； b) a barrier coating surrounding the multilayer tablet core； and c) a gastro-resistant coating surrounding the barrier coating.
