Gregory F. Payne;Chao Zhu;Matthew B. Dowling;Srinivasa R. Raghavan
发明人:
Srinivasa R. Raghavan,Gregory F. Payne,Chao Zhu,Matthew B. Dowling
申请号：
US12077173
公开号：
US09066885B2
申请日:
2008.03.17
申请国别(地区):
US
年份:
2015
代理人:
摘要：
The present invention provides a novel biomaterial which is a hybrid, self-assembling biopolymeric networked film that is functionalized through hydrophobic interactions with vesicles loaded with bioactive agents. The biomaterial compound is a polymeric network of hydrophobically modified chitosan scaffolds that is taken from solution and formed as a solid film. This solid state film is capable of hydrophobic interactions with the functionalized vesicles. The vesicles include one or more lamellar structures forming one or more nano-compartments that are capable of containing similar or alternative active moieties within. Use of the film results in a degradation of the chitosan scaffold thereby releasing the active moieties within the vesicles from the scaffold. Application of the current invention occurs through various delivery mechanisms and routes of administration as will be described herein.
