GHAYUR, TARIQ,LIU, JUNJIAN,JAKWAY, JAMES J.,TALANIAN, ROBERT V.,BENATUIL, LORENZO
申请号：
PE0024802012
公开号：
PE06142013A1
申请日:
2011.06.23
申请国别(地区):
PE
年份:
2013
代理人:
摘要：
Refers to a Binding Protein that comprises a First and a Second polypeptide Chain where the polypeptide Chain comprising VD1 VD2 (x1) - N - (N - (x2) where is a domain variable First: VD1, VD2 is a Second variable Domain c is a domain X1 is a Constant Connector with co That is not ndicion CH1 x2 is an FC region FC is a variant of the FC region of a sequenceImmunoglobulin n is 0 - 1, where the first and second VD1 Domains in the polypeptide Chain forming a First Binding Site Functional domains and VD2 White in the first and second polypeptide Chain forming a Second White Functional binding site, and where the Protein or Nion has the capacity to bind TNF and tweak,Where: (i) the variable domains that form a functional binding site for TNF White comprise Three CDRs of SEQ ID no. 28, SEQ ID no. 29 and (ii) the variable domains that form a functional binding site for white tweak include: Three CDRs of SEQ ID no. 30, SEQ ID no. 31 or three CD RS of the SEQ ID no. 32 and SEQ ID no. 33.Referring also to the binding protein polypeptide Chains which comprises two first and Two second polypeptidic Chains. In addition to such a Pharmaceutical composition. This Binding Protein is useful in the treatment of acute and chronic inflammatory diseases and cancer.SE REFIERE A UNA PROTEINA DE UNION QUE COMPRENDE UNA PRIMERA Y UNA SEGUNDA CADENA DE POLIPEPTIDICA EN DONDE LA CADENA POLIPEPTIDICA COMPRENDE VD1-(X1)n-VD2-C-(X2)n EN DONDE: VD1 ES UN PRIMER DOMINIO VARIABLE VD2 ES UN SEGUNDO DOMINIO VARIABLE C ES UN DOMINIO CONSTANTE X1 ES UN CONECTOR CON LA CONDICION QUE NO SEA CH1X2 ES UNA REGION Fc Fc ES UNA VARIANTE DE LA SECUENCIA DE LA REGION Fc DE UNA INMUNOGLOBULINA n ES 0 - 1 EN DONDE LOS DOMINIOS VD1 EN DICHA PRIMERA Y SEGUNDA CADENA DE POLIPEPTIDOS FORMAN UN PRIMER SITIO DE UNION BLANCO FUNCIONAL Y LOS DOMINIOS VD2 EN DICHA PRIMERA Y SEGUNDA CADENA DE POLIPEPTIDOS FORMAN UN SEGUNDO SITIO DE UNION BLANCO FUNCIONAL, Y DONDE LA PROTEINA DE UNION TIENE LA CAPACIDAD DE UNIR TNF Y TWEAK
