Dolle, Roland E.,Le Bourdonnec, Bertrand,Martin, Pierre,Moessner, Christian Steffen,Spindler, Felix Herbert,Spielvogel, Dirk Jost
申请号：
AU2012284127
公开号：
AU2012284127A1
申请日:
2012.07.17
申请国别(地区):
AU
年份:
2013
代理人:
摘要：
Novel processes for the preparation of peripheral opioid antagonist compounds and intermediates thereto. The compounds prepared by the present processes may be useful, for example, as antagonists to the mu, kappa and delta opioid receptors, and thereby may be useful in the treatment of gastrointestinal motility disorders, and in preventing peripheral opiate induced side effects. The present processes may offer improved yields, chemical or stereochemical purity, ease of preparation and/or isolation of intermediates and final product, and more industrially useful reaction conditions and workability.
