The present invention is directed to compounds that are inhibitors of the deubiquitinating enzyme, USP14, encompassed by the Formulae (I), (la) and (lb), compositions thereof, methods for the treatment of a condition associated with a dysfunction in proteostasis, methods for enhancing proteasome activity and methods for treating conditions associated with proteostasis dysfunction, such as cancer or tumor.Cette invention concerne des composés de Formule (I), (Ia) ou (Ib), des compositions les contenant et des méthodes destinées à traiter une affection associée à un dysfonctionnement de la protéostasie.
