Bloembergen, Steven,McLennan, Ian J.,Jones, Nathan,Ganesh Shermon, Areet Krsna,Elsayed, Abdel,Lui, Juewen
申请号：
AU2012318273
公开号：
AU2012318273A1
申请日:
2012.09.21
申请国别(地区):
AU
年份:
2013
代理人:
摘要：
#$%^&*AU2012318273A120130620.pdf#####ABSTRACT A delivery device for a active agent comprises nanoparticles based on a biopolymer such as starch. The delivery device may also be in the form of an aptamer-biopolymer-active agent conjugate wherein the aptamer targets the device for the treatment of specific disorders. The nanoparticles may be made by applying a high shear force in the presence of a crosslinker. The particles may be predominantly in the range of 50-150 nm and form a colloidal dispersion of crosslinked hydrogel particles in water. The biopolymer may be functionalized. The aptamer may be conjugated directly to the crosslinked biopolymers. The active agent may be a drug useful for the treatment of cancer. The delivery device survives for a period of time in the body sufficient to allow for transport and uptake of the delivery device into targeted cells. The degree of crosslinking can provide a desired release profile of the active agent at, near or inside the target cells. 37
