Disclosed are compositions comprising polyethylene glycol (PEG) having a weight average molecular weight of 800 or greater and a concentration of 30mg/ml or greater for use in preventing and/or treating head and neck squamous cell carcinoma (HNSCC). Methods of preventing and/or treating HNSCC are also disclosed.本發明揭示包含重量平均分子量為800或大於800且濃度為30mg/ml或大於30mg/ml之聚乙二醇(PEG)的組成物,其用於預防及/或治療頭部和頸部鱗狀細胞癌(HNSCC)。本發明亦揭示預防及/或治療HNSCC之方法。