Difluoroethylpyridine derivatives as NR2B NMDA receptor antagonists

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专利权人:

Rugen Holdings (Cayman) Limited

发明人:

Gideon Shapiro

申请号：

US15315812

公开号：

US10030026B2

申请日:

2015.06.03

申请国别(地区):

US

年份:

2018

代理人:

摘要：

Disclosed are chemical entities of formula (I) wherein X, Y, Z, R1, R3, R4, R5 and R6 are defined herein, as NR2B subtype selective receptor antagonists. Also disclosed are pharmaceutical compositions comprising a chemical entity of formula (I), and methods of treating various diseases and disorders associated with NR2B antagonism, e.g., diseases and disorders of the CNS, such as depression, by administering a chemical entity of formula I.

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