The Regents of The University of California;United States Government Represented by The Department of Veterans Affairs
发明人:
Samuel S. Murray,Elsa J. Murray,Keyvan Behnam
申请号:
US14263080
公开号:
US20150056700A1
申请日:
2014.04.28
申请国别(地区):
US
年份:
2015
代理人:
摘要:
A cyclized peptide designated BMP Binding Peptide (BBP) is a synthetic peptide that avidly binds rhBMP-2. BBP increases the overall osteogenic activity of rhBMP-2, increases the rate at which rhBMP-2 induces bone formation, and BBP induces calcification alone. Compositions and substrates including BBP, and methods of using BBP are useful in therapeutic, diagnostic and clinical applications requiring calcification and osteogenesis.