Process for the preparation of key intermediates for the synthesis of rosuvastatin or pharmaceutically acceptable salts thereof

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专利权人:

发明人:

ANDRENSEK SAMO,ANZEL JOLANDA,HOCEVAR MARJETA,CASAR ZDENKO

申请号：

IN6089/CHENP/2012

公开号：

IN2012CN06089A

申请日:

2012.07.11

申请国别(地区):

IN

年份:

2015

代理人:

摘要：

The present invention relates in general to the field of organic chemistry and in particular to a process for the preparation of 5 ((E) 2 ((2S 4R) 4 hydroxy 6 oxotetrahydro 2H pyran 2 yl)vinyl) 4 (4 fluorophenyl) 6 isopropyl 2 (N methylmethanesulfonylamino)pyrimidine (RSVL) as well as a process for preparing crystalline 5 ((E) 2 ((2S 4R) 4 (tert butyldimethylsilyloxy) 6 oxotetrahydro 2H pyran 2 yl)vinyl) 4 (4 fluorophenyl) 6 isopropyl 2 (N methylmethanesulfonylamino)pyrimidine (RSVLTBS) useful as key intermediates for the preparation of rosuvastatin or pharmaceutically acceptable salts thereof.

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