Meldrum acid, barbituric acid, and pyrazolone derivatives as HNO donors substituted with hydroxylamine

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专利权人:

ザ・ジョンズ・ホプキンス・ユニバーシティ

发明人:

ガスリー，ダリル・エイ,トスカーノ，ジョン・ピー,ガスリー,ダリル・エイ,トスカーノ,ジョン・ピー

申请号：

JP2014537151

公开号：

JP6177246B2

申请日:

2012.10.16

申请国别(地区):

JP

年份:

2017

代理人:

摘要：

The disclosed subject matter provides certain N-substituted hydroxylamine derivative compounds, pharmaceutical compositions and kits comprising such compounds, and methods of using such compounds or pharmaceutical compositions. In particular, the disclosed subject matter provides methods of using such compounds or pharmaceutical compositions for treating, preventing, or delaying the onset and/or development of a disease or condition. In some embodiments, the disease or condition is selected from cardiovascular diseases, ischemia, reperfusion injury, cancerous disease, pulmonary hypertension and conditions responsive to nitroxyl therapy.

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