Vahe Bedian;Avril Alfred;Julie Rinkenberger;Ian Foltz;Simon Thomas Barry
发明人:
Julie Rinkenberger,Ian Foltz,Avril Alfred,Simon Thomas Barry,Vahe Bedian
申请号：
US12782335
公开号：
US08398975B2
申请日:
2010.05.18
申请国别(地区):
US
年份:
2013
代理人:
摘要：
Targeted binding agents, such antibodies directed to the antigen αVβ6 and uses of such agents are described. In particular, fully human monoclonal antibodies directed to the antigen αVβ6 are disclosed. Nucleotide sequences encoding, and amino acid sequences comprising, heavy and light chain immunoglobulin molecules, particularly sequences corresponding to contiguous heavy and light chain sequences spanning the framework regions and/or complementarity determining regions (CDR's), specifically from FR1 through FR4 or CDR1 through CDR3 are disclosed. Hybridomas or other cell lines expressing such immunoglobulin molecules and monoclonal antibodies are also disclosed.
