THE BOARD OF REGENTS OF THE UNIVERSITY OF TEXAS SYSTEM
发明人:
Pei-Yong SHI,Xuping XIE,Chao SHAN
申请号：
US16485818
公开号：
US20200197505A1
申请日:
2018.02.14
申请国别(地区):
US
年份:
2020
代理人:
摘要：
The present invention discloses a live attenuated strain of Zika virus (ZIKV) having a deletion in the 3′； untranslated region (3′；UTR) of the viral genome, which may affect viral RNA synthesis and sensitivity to type I interferon inhibition, but may not affect viral RNA translation. The present invention also discloses the use of these live attenuated ZIKV strains in the preparation of ZIKV vaccines and for providing immunoprotection against ZIKV infection and congenital ZIKV syndrome, particularly in pregnant females.
