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New alkylating agents
- 专利权人:
- Nerviano Medical Sciences S.r.l.
- 发明人:
- BERIA, Italo,CARUSO, Michele,LUPI, Vittoria,ORSINI, Paolo,SALSA, Matteo,PANZERI, Achille
- 申请号：
- ES13715931
- 公开号：
- ES2755719T3
- 申请日:
- 2013.03.28
- 申请国别(地区):
- ES
- 年份:
- 2020
- 代理人:
- 摘要：
- A compound of formula (IV) ** Formula ** or a pharmaceutically acceptable salt thereof, selected from the group consisting of: N- [6- (2,5-dioxo-2,5-dihydro-1H-pyrrole-1 -yl) hexanoyl] -L-valyl-N5-carbamoyl-N- [4 - ({[{3 - [({[(8S) -8- (chloromethyl) -1-methyl-6- ({5- [ ({5- [2- (pyrrolidin-1-yl) ethoxy] -1H-indole-2-yl} carbonyl) amino] -1H-indole-2-yl} carbonyl) -7,8dihydro-6H-thieno [3 , 2-e] indole-4-yl] oxy} carbonyl) (methyl) amino] -2,2-dimethylpropyl} (methyl) carbamoyl] oxy} methyl) phenyl] -L-ornithinamide, N- [6- (2 , 5-dioxo-2,5-dihydro-1H-pyrrol-1-yl) hexanoyl] -L-valyl-N5-carbamoyl-N- [4 - ({[{3 - [({[(8R) -8 - (chloromethyl) -1-methyl-6- ({5 - [({5- [2- (pyrrolidin-1-yl) ethoxy] -1H-indole-2-yl} carbonyl) amino] -1H-indole- 2-yl} carbonyl) -7,8dihydro-6H-thieno [3,2-e] indole-4-yl] oxy} carbonyl) (methyl) amino] -2,2-dimethylpropyl} (methyl) carbamoyl] oxy} methyl) phenyl] -L-ornithinamide, N- [6- (2,5-dioxo-2,5-dihydro-1H-pyrrol-1-yl) hexanoyl] -L-valyl-N5-carbamoyl-N- [4 - ({[{3 - [({[(8S) -8- (chloromethyl) -1-methyl-6- ({5- [2- (pyrrolidin-1-yl) ethoxy] -1H-indole-2- il} carbonyl) -7.8 -dihydro-6H-thieno [3,2-e] indole-4yl] oxy} carbonyl) (methyl) amino] -2,2-dimethylpropyl} (methyl) carbamoyl] oxy} methyl) phenyl] -L-ornithinamide, N - [6- (2,5-dioxo-2,5-dihydro-1H-pyrrol-1-yl) hexanoyl] -L-valyl-N5-carbamoyl-N- [4 - ({[{3 - [({ [(8R) -8- (chloromethyl) -1-methyl-6- ({5- [2- (pyrrolidin-1-yl) ethoxy] -1H-indole-2-yl} carbonyl) -7,8-dihydro -6H-thieno [3,2-e] indole-4yl] oxy} carbonyl) (methyl) amino] -2,2-dimethylpropyl} (methyl) carbamoyl] oxy} methyl) phenyl] -L-ornithinamide, N- [ 6- (2,5-dioxo-2,5-dihydro-1H-pyrrol-1-yl) hexanoyl] -L-valyl-N5-carbamoyl-N- [4 - ({[(3 - {[({( 8S) -8- (chloromethyl) -1-methyl-6- [(2E) -3- {5- [2- (pyrrolidin-1-yl) ethoxy] -1H-indole-2-yl} prop-2- enoyl] -7,8-dihydro-6H-thieno [3,2e] indole-4-yl} oxy) carbonyl] (methyl) amino} -2,2-dimethylpropyl) (methyl) carbamoyl] oxy} methyl) phenyl] -L-ornithinamide, N- [6-
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- 中国工程科技知识中心
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- http://www.ckcest.cn/home/
