A sterilization system and method are provided that convert a sterilant solution to a vapor using an outgassing process that removes sterilant vapor from a solution (e.g., liquid) or a solid and delivers the sterilant vapor into an interior of an enclosure vessel. The interior of the enclosed vessel is maintained at a vacuum pressure. Once the sterilant vapor enters the interior of the vessel, the vapor expands to all surfaces to effectively sterilizing the interior of the vessel.
