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Azetidinecarboxylic acid derivative and medicinal use thereof
专利权人:
ONO PHARMACEUTICAL CO.; LTD.
发明人:
HABASHITA, HIROMU,KURATA, HARUTO,NAKADE, SHINJI
申请号:
ES11168698
公开号:
ES2519346T3
申请日:
2005.12.12
申请国别(地区):
ES
年份:
2014
代理人:
摘要:
Compound represented by the formula (IC-2): ** Formula ** where Z represents (1) a carboxyl group that can be protected with C1-20 alkyl, (2) a hydroxy group that can be protected with C1-20 alkyl , (3) a hydroxamic acid group that can be protected with C1-20 alkyl, (4) a sulfonic acid group that can be protected with C1-20 alkyl, (5) a boronic acid group that can be protected with C1- alkyl 20, (6) a carbamoyl group that can be protected with C1-20 alkyl, (7) a sulfamoyl group that can be protected with C1-20 alkyl, (8) a group -P (>; = O) (OR2) ( OR3), where R2 and R3 each independently represent a hydrogen atom and a C1-8 alkyl group, or R2 and R3 are joined together to represent a C2-4 alkylene group, or (9) a tetrazolyl group, R1 represents a halogen atom, C1-8 alkyl which may have a substituent or substituents, or C1-8 alkoxy which may have a substituent or substituents, the "substituent" e n "which may have a substituent or substituents" is selected from (1) C1-20 alkyl, (2) C2-20 alkenyl, (3) C2-20 alkynyl, (4) C1-20 alkylidene, (5) a group cyclic, (6) C1-20 alkyl substituted with a cyclic group, (7) oxo, (8) hydroxy, (9) C1-20 alkyloxy, (10) C2-20 alkenyloxy, (11) C2-20 alkynyloxy, ( 12) hydroxy protected with a cyclic group, (13) C1-20 acyloxy, (14) thioxo, (15) mercapto, (16) C1-20 alkylthio, (17) C2-20 alkenylthio, (18) C2-20 alkylthio , (19) mercapto substituted with a cyclic group, (20) C1-20 alkylsulfinyl, (21) C2-20 alkenylsulfinyl, (22) C2-20 alkylsulfinyl, (23) sulfinyl substituted with a cyclic group, (24) C1 alkylsulfonyl -20, (25) C2-20 alkenylsulfonyl, (26) C2-20 alkylsulfonyl, (27) sulfonyl substituted with a cyclic group, (28) C1-20 alkylsulfonyl substituted with a cyclic group, (29) sulfino, (30) sulfo, (31) sulfamoyl, (32) carboxy, (33) C1-20 acyl, (34) C1-20 acyl substituted with a cyclic group, (35) carbonyl substituted with a cyclic group, (36) carbamoyl, (37) cyano, (38) amidino, (39) nitro, (40) nitroso, (41) imino, (42) amino, (43)
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