The present disclosure provides systems and methods for imaging and display of features of a region of interest such as a portion of a body of a patient. A first imaging portion of the system is used to cause an interaction of an imaging beam with an underlying feature of a region of interest. A reflected or returned portion of said imaging beam is detected by a detector which then provides an output to control a display portion of the system for displaying an image corresponding to that which was detected. The system can be used for guiding or assisting clinical or industrial operations or for diagnosis of medical conditions and other uses within medicine, industry and others.
