TSAI, HUAI JEN,蔡怀桢,蔡懷楨,LEE, HUNG CHIEH,李鸿杰,李鴻杰,LO, HAO CHAN,罗浩展,羅浩展,DAI, MING SHEN,戴明燊,戴明燊,CHEN, YING SHIN,陈颖信,陳穎信,SU, MEI YAN,苏玫燕,蘇玫燕
申请号：
TW102123039
公开号：
TWI508727B
申请日:
2013.06.27
申请国别(地区):
TW
年份:
2015
代理人:
摘要：
Amiodarone is a drug for treating arrhythmias, and its major role is to control the current conduction in the heart muscle, relax the over activated cardiac muscle and make the rate or rhythm of the heart beat to achieve the appropriate level. The present invention is related to the new use for inhibiting cancer metastasis. The role of Amiodarone to inhibit cancer metastasis is achieved by inhibiting EGFR signaling that can further affect the expression of snail and E-cadherin.胺碘酮(Amiodarone)是一種治療心律不整的藥物,其主要的作用在於控制心臟肌肉內電流的傳導、鬆弛過度活化的心肌,使心臟跳動的速率或節奏達到適當的程度。本發明主要係關於胺碘酮用於抑制癌細胞的轉移(metastasis)之用途。胺碘酮藉由抑制EGFR訊息傳導進而影響snail與E-cadherin的表現以達到抑制癌細胞轉移的作用。
