THE NATIONAL INSTITUTE FOR BIOTECHNOLOGY IN THE NEGEV LTD.
发明人:
PORGADOR, ARI-ANGEL
申请号：
CA3047230
公开号：
CA3047230A1
申请日:
2017.12.14
申请国别(地区):
CA
年份:
2018
代理人:
摘要：
The present invention provides a monoclonal antibody or an antigen-binding portion thereof having increased binding affinity to cytoplasmic PCNA and blocks its interaction with NKp44. The present invention further provides use of the antibody or an antigen-binding portion thereof in the treatment of diseases associated with elevated expression of NKp44, such as cancer.
