Disclosed is an immunogenic composition comprising at least one inactivated dengue virus antigen and an aluminium-free adjuvant, wherein the adjuvant comprises a combination of 3-Deacylated monophosphoryl lipid A (3D&ndashMPL) and QS21. Also disclosed is a method for making the said composition and its use for preventing, ameliorating or treating disease caused by dengue virus in a subject.