The present invention relates to compounds of formula (I) or pharmaceutically acceptable salts thereof, wherein Q, T, V, W, X, Y, Z, ring A, R1, R2, R3, R4, R5, R5a, R6, R7, R8, R9, R10, R11, R12, R13, R14, R15, R16, R17 and m are defined herein. There novel pyrrolopyrimidine and purine derivatives are useful in the treatment of abnormal cell growth, such as cancer, in mammals. Additional embodiments relate to pharmaceutical compositions containing the compounds and to methods of using the compounds and compositions in the treatment of abnormal cell growth in mammals.本發明係關於式(I)化合物：或其醫藥學上可接受之鹽，其中Q、T、V、W、X、Y、Z、環A、R1、R2、R3、R4、R5、R5a、R6、R7、R8、R9、R10、R11、R12、R13、R14、R15、R16、R17及m係如本文中所定義。此等新穎的吡咯并嘧啶及嘌呤衍生物適用於治療哺乳動物之異常細胞生長，諸如癌症。其他實施例係關於含有此等化合物的醫藥組合物，及使用此等化合物及組合物治療哺乳動物之異常細胞生長的方法。
