Process for preparing the anti tumor agent 6 (7 ((1 aminocyclopropyl) methoxy) 6 methoxyquinolin 4 yloxy) n methyl 1 naphthamide and its crystalline

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专利权人:

发明人:

CHEN GUOQING PAUL

申请号：

IN6389/DELNP/2015

公开号：

IN2015DN06389A

申请日:

2015.07.21

申请国别(地区):

IN

年份:

2016

代理人:

摘要：

The present invention relates a new process to synthesize 6 (7 ((l aminocyclo propyl) methoxy) 6 methoxyquinolin 4 yloxy) N methyl l naphthamide (AL3810) by deprotection of substituted benzyl 1 ((6 methoxy 4 (5 (methylcarbamoyl)naphthalen 2 yloxy)quinolin 7 yloxy) methyl)cyc lopropylcarbamate (Formula I) under a diluted or weak acidic condition. A stable crystalline form of 6 (7 ((l aminocyclo propyl) methoxy) 6 methoxyquinolin 4 yloxy) N methyl 1 naphthamide has also been prepared.

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